GABA is a biogenic amino acid that is synthesized in the brain. It represents a major inhibitory neurotransmitter with a large role in the central nervous system (CNS) and the metabolic processes involved in brain cells.
GABA is associated with states of relaxation and mental concentration. It helps us to fight chronic anxiety by not allowing neurons to overstimulate. GABA causes muscle relaxation, but its sharp deficiency can lead to convulsions.
The GABA synthesis is a complex process that ensures proper functioning of the brain in various departments - 66% of the CNS includes GABA transmission. This acid is formed in the body from another amino acid - glutamic acid (glutamate).
Its function is to lower the neuron activity, and thereby to protect the nerve cells from "overheating." GABA is associated with specific receptors; it mediates the inhibitory processes in the CNS. In the brain, there are at least two molecular forms of glutamate decarboxylase (glutamate decarboxylase (GAD)) - the main enzyme responsible for the synthesis of GABA.
Two forms-GAD65 and GAD67 are the products of two genes and differ in molecular weight, reaction with co-factors, as well as in the level of expression in different brain regions. GAD65 is localized in the nerve terminals to a greater extent than GAD67, which is distributed evenly between the cells.
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Research and Studies on GABA Show That It Has the Following Actions
- GABA is shown to naturally increase levels of growth hormone (HGH - Human Growth Hormone);
- Helps to reduce stress;
- Relaxation of the body;
- Improves sleep quality
- Increases energy levels;
- Improves the quality of physical exercise;
- Improves sexual activity;
- Increase muscle mass;
- Reduces body fat;
- Helps with "forgetting";
- Has an anti-aging effect.
Intake of GABA, for the increase of growth hormone levels in the majority of cases, appears much safer than the artificial supplementation of HGH. Aminallon (750 mg capsule) is one of the products which contain GABA as their active ingredient.
Action
GABA is a universal suppressor (hyperpolarizing) CNS mediator. It improves the absorption of glucose and redox processes in neurons. GABA does not cross the blood-brain barrier in the body but leads to the increased cerebral circulation.
As a result, there is an improvement in the thinking process, memory, mental and motor activity, vestibular function. In combination with niacin and inositol, GABA has an effect on anxiety, worry, and stress; it reaches the motor centers of the brain and occupies the receptor sites.
GABA can be taken for relaxing the body and its effect can be similar to that of diazepam (Valium), chlordiazepoxide (Librium) and other tranquilizers, but without serious risk of the typical overdose.
Indication
In cases of the cerebrovascular disease, after stroke, posttraumatic encephalopathy, brain stem stroke, other forms of encephalopathy, in cases of impaired mental development in children and adults.
Application and Dosage
A standard dose ranges between 250 mg - 750 mg taken two or three times throughout the day. In adults - 2-3 tablets 3 times a day for 1 to 3-4 months.
If necessary, the dose may be increased to 5 tablets, 3 times a day. The duration of the dosing is 6-8 weeks.
Side Effects
GABA (Aminalon) is well tolerated. Rare side effects: insomnia, nausea, and fullness in the abdomen, vomiting, shortness of breath, numbness of the extremities (side effect disappears after dose reduction). GABA can be used by athletes, but after assessing general health, benefits, and potential harm.
